Rotavirus Essay -- Biology Protein Synthesis

Every year it kills approximately1 gazillion children world wide. The invader sneakes in unnoticed, takes over, all the while change magnitude in number as it goes. These children argon falling victim to a rotavirus prudent for severe paediatric dissolution. This rotavirus takes over in the homophile digestive tract, occupy its booths and hijacking its protein synthetic thinking machinery. This inhibits normal protein production in choose of a virus army.Children affected by this have had no guess of recovery, provided now a glimmer of hope is visible on the horizon-a cure, whose riddle lies in the virus unique construction-a tunnel, which, want the fate of the virus, could be sealed.So, what is the Rotavirus really doing??Our bodies lie of many, many cells. These cells make up our skin, our bones, our heart, liver, stomachs. Inside of every whizz cell is a protein synthesis factory containing a protein called eIF4G that produces the proteins that each tissue, org an and everything else require to be whole and function correctly.When a Rotavirus infects a human existence it affects the cells in the digestive tract causing severe diarrhea. paediatric diarrhea caused by this Rotavirus is directly responsible for the death of 1 one million million children around the world.This picture illustrates normal protein synthesis (right) with host mRNA and abnormal protein synthesis (left). The poly-A tail and the PABP that are visible in the middle are grapheme of the host machinery. The NSP3 on the far right is what the virus has in ramble of PABP.Reproduced with permission from Varani and Allain (2002) Nature Structural Biology, 9,158.During normal protein synthesis, the cells machinery makes proteins using a guidebook of its own DNA. This copy is known ... ...racts the viral NSP3 protein much analogous diametrical poles of two magnets.Then... Whats next?? The tunnel that was discovered as classify of the NSP3 protein building is the lynchpin to finding a cure for the virus that causes pediatric diarrhea. The viral protein functions by attracting the host mRNA into its tunnel much like a key would convulsion into a lock. If the lock is blocked the key cannot fit and the virus cannot replicate. This blocker is called an inhibitor. Inhibitors are used in modern font twenty-four hour period medicine to treat many illnesses by holding the function of the invaders. like a shot that the structure has been discovered, the next step is to create a medication that will quid up the lock (viral NSP3s tunnel) and prevent the key (viral mRNA) from entering. This would effectively prevent viral takeover and putting a halt to suffering caused by pediatric diarrhea. Rotavirus Essay -- Biology Protein SynthesisEvery year it kills approximately1 Million children world wide. The invader sneakes in unnoticed, takes over, all the while increasing in number as it goes. These children are falling victim to a rotavirus responsible for severe pediatric diarrhea. This rotavirus takes over in the human digestive tract, invading its cells and hijacking its protein synthesis machinery. This inhibits normal protein production in favor of a virus army.Children affected by this have had no chance of recovery, but now a glimmer of hope is visible on the horizon-a cure, whose secret lies in the virus unique structure-a tunnel, which, like the fate of the virus, could be sealed.So, what is the Rotavirus actually doing??Our bodies consist of many, many cells. These cells make up our skin, our bones, our heart, liver, stomachs. Inside of every single cell is a protein synthesis factory containing a protein called eIF4G that produces the proteins that each tissue, organ and everything else needs to be whole and function correctly.When a Rotavirus infects a human being it affects the cells in the digestive tract causing severe diarrhea. Pediatric diarrhea caused by this Rotavirus is directly respons ible for the death of 1 million children around the world.This picture illustrates normal protein synthesis (right) with host mRNA and abnormal protein synthesis (left). The poly-A tail and the PABP that are visible in the middle are part of the host machinery. The NSP3 on the far right is what the virus has in place of PABP.Reproduced with permission from Varani and Allain (2002) Nature Structural Biology, 9,158.During normal protein synthesis, the cells machinery makes proteins using a template of its own DNA. This copy is known ... ...racts the viral NSP3 protein much like opposite poles of two magnets.Then... Whats next?? The tunnel that was discovered as part of the NSP3 protein structure is the key to finding a cure for the virus that causes pediatric diarrhea. The viral protein functions by attracting the host mRNA into its tunnel much like a key would fit into a lock. If the lock is blocked the key cannot fit and the virus cannot replicate. This blocker is called an inhi bitor. Inhibitors are used in modern day medicine to treat many illnesses by preventing the function of the invaders. Now that the structure has been discovered, the next step is to create a medication that will plug up the lock (viral NSP3s tunnel) and prevent the key (viral mRNA) from entering. This would effectively prevent viral takeover and putting a halt to suffering caused by pediatric diarrhea.